Autocatalytic base editing for RNA-responsive translational control

Autocatalytic base editing for RNA-responsive translational control

Blog Article

Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics.Here the authors engineer click here programmable RNA sensors, DART VADARs, in which ADARs autocatalytically convert target hybridization into a translational chocolate chip cookie purse output, thus amplifying editing by endogenous ADAR via positive feedback and conferring high dynamic range and a small genetic footprint.